Listeria
Listeria monocytogenesis a bacterium in close contact with humans. The body's immune system against
Listeria has established a innate immune response. This is a very delicate and can not be copied immune mechanism, it has three advantages:
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Advaxis to Listeria-based cancer vaccines use of biological engineering approach combines functionality with powerful immune adjuvant LLO protein and cancer antigen. The fusion protein can trigger the innate and acquired immune system to fight the cancer cells in the body. Advaxis cancer vaccine-induced immune response so far in the industry is the most comprehensive and the most powerful.
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Regulatory T cells and myeloid-derived suppressor cells within the tumor protection against tumor cytotoxic T cells attacks. Advaxis cancer vaccines can reduce the tumor inside the regulatory T cells and myeloid suppressor cells, and thus enhance the cytotoxic T cells effective attack.
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Another feature Advaxis cancer vaccines is that they not only increase killer T cells within the tumor and the change in the tumor killer T calls and regulatory T cells (regulatory T cell) ratio increase 1:1.3 to 1:22.7 (increase in tumor killing ratio).
